AQUASOMES DRUG DELIVERY PDF

Mar 1, Aquasomes are spherical 60– nm particles used for drug and antigen delivery. Aquasomes discovery comprises a principle from. Sep 6, Aquasomes are spherical 60– nm particles used for drug and antigen delivery. Aquasomes discovery comprises a principle from. Mar 13, PDF | Aquasomes are three-layered ceramic core based carbohydrate coated nanoparticle delivery systems with bioactive molecules adsorbed.

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Aquasomes discovery comprises a principle from microbiology, food chemistry, biophysics and many discoveries including solid phase synthesis, supramolecular chemistry, molecular shape change and self assembly.

Aquasomes: a promising carrier for peptides and protein delivery.

This property of maintaining the conformational integrity of bioactive molecules has led to the proposal that aquasomes have potential as a carrier system for delivery of peptide, protein, hormones, antigens and genes to specific sites. Aquasomes are spherical 60— nm particles used for drug and antigen delivery.

Oral delivery of enzymes like serratiopeptidase has also been achieved. The brushite is unstable and converts to hydroxyapatite upon prolong storage. Aquasome deliver their content through specific targeting, molecular sheiling and slow sustained release process. This property of maintaining the conformational integrity of bioactive molecules has led to the proposal that aquasomes have potential as a carrier system for delivery of peptide-based pharmaceuticals.

This article discusses the problems faced in the delivery of clinically important peptides and presents aquasomes as a reliable approach to troubleshoot them. Aquasomes are one of the most recently developed delivery systems that are finding a niche as peptide and protein carriers.

Aquasomes are nanoparticulate carrier system but instead of being simple nanoparticles these arse three layered self assembled structures, comprised of a solid phase nanocrystalline core coated with oligomeric film to which biochemically active molecules are adsorbed with or without modification. Their intended route of administration is parenteral and with advancement of research in this field, other routes might be contemplated.

Calcium phosphate is the core of interest, owing to its natural presence in the body. They comprise a central solid nanocrystalline core coated with polyhydroxy oligomers onto which biochemically active molecules are adsorbed.

The solid core provides the structural stability, while the carbohydrate coating protects against dehydration and stabilizes the biochemically active molecules. Aquasome technology represents a patform system for conformational integrality and biochemical stability of bioactives. Article Information Sr No: The solid core provides the structural stability, while the carbohydrate coating protects against dehydration and stabilizes the biochemically active molecules.

Aquasomes: a promising carrier for peptides and protein delivery.

Hydroxyapatite seems, therefore, a better core for the preparation of aquasomes. These are nanoparticulate carrier systems with three-layered self-assembled structures.

It is widely used for the preparation of implants for drug delivery. The delivery system has been successfully utilized for the delivery of insulin, hemoglobin, and various antigens.

Their large sized and active surfaces enable them to be loaded with water insoluble drugs through non covalent processes.

Three types of core materials are mainly used for producing aquasomes: Nanobiopharmaceutics involves delivery of biopharmaceutical product through different biomaterials like multifunctional nanoparticles, quantum dots, aquasomes, superparamagnetic iron oxide crystals, and liposomes dendrimers. Department of Pharmacology, K.

Nanotechnology has emerged fields of biomedical research in the last few decades the dflivery context is an attempt to present the brief information about nanobiotechnological applications. This article reviews the principles of self assembly, the challenges of maintaining both the conformational integrity and biochemical activity of immobilized surface pairs, and the convergence of these principles into a single functional composition.