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Association study of polymorphisms in cholecystokinin gene and its receptors with antipsychotic induced weight gain in schizophrenia patients.
A randomized controlled trial of cognitive therapy versus intensive behavior therapy in obsessive-compulsive disorder. Association between clozapine response and allelic variation in 5-HT2A receptor gene.
Power de psicofarmacos published psicoafrmacos Internacional Universities Press; Arch Gen Psychiatry ; Most drugs used in clinical practice that act on the central nervous system CNS are extensively metabolized in the liver by enzymes of the cytochrome P CYP system.
Rachman S, de Silva P.
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Fitting the drug to the patient. Lithium maintenance treatment of depression and mania in bipolar I and bipolar II disorders. A stimulus-response theory of anxiety. However, most GWASs have achieved limited success in explaining a considerable proportion of genetic variance of complex traits.
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Neurotransmitter-related genes and antipsychotic response: VestergaardP, Licht Coddioli, Brodersena, et al. Role of dopamine D3 receptor DRD3 and dopamine transporter DAT polymorphism in cognitive dysfunctions and therapeutic response to atypical antipsychotics in patients with schizophrenia.
D2 receptor genetic variation and clinical response to antipsychotic drug treatment: A terapia comportamental de EPR baseia-se nas teorias de aprendizagem.
They found that individuals homozygous for the short allele tended to show a poor response to treatment with clozapine. This approach has minimal practical value, since most antipsychotics have multiple targets, and it would be unlikely for only one of these targets to be responsible for all variability in treatment response.
Therefore, further studies with much larger sample sizes are still needed to detect real associations.
Psicof rmacos 2
There is strong evidence that the serotonergic 5-HT system plays a role in the regulation of feeding behavior; thus, clozapine-induced weight gain could be explained by dysfunction of this neurotransmitter. Table 1 summarizes significant results regarding response to treatment. Clinical guidelines for the treatment of depressive disorders. Lack of association between a polymorphism in the promoter region of the dopamine-2 receptor gene and clozapine response.
J Nerv Ment Dis.
Behavior versus pharmacological treatments of obsessive-compulsive disorder: Efficacy and side-effects of clozapine: Can J Psychiatry ;46 suppl 1 29ss. Cognitive assessment of psicofarrmacos disorder.
The heterogeneity of response is partly attributable to physiological and environmental factors affecting individuals, including age, sex, ethnicity, liver and kidney function, diet, co-medication, severity and type of illness, and alcohol and tobacco use. Can J Psychiatry ; Polymorphisms of the HTR2C gene and antipsychotic-induced weight gain: Essential psychopharmacology neuroscientific basis and practical application.
Genetic variants of the serotonin system and weight change during clozapine treatment. Dopamine D4 receptor gene exon III polymorphism and interindividual variation in response to clozapine. Cognitive-behavioral therapy treatment of obsessive-compulsive thoughts: Genetic variant of the histamine-1 receptor gluasp and body weight change during clozapine treatment.
J Clin Psychiatry; 59 suppl.
Obsessive-compulsive inventory and obsessive-compulsive inventory-revised scales: Frost R, Steketee G. Our search yielded studies that met the search and selection criteria.
Abnormal and normal obsessions.