LRRTM1 leucine rich repeat transmembrane neuronal 1 [ (human)]. Gene ID: , updated on 7-Dec This gene is imprinted, being predominantly expressed from the paternal allele and showing a variable pattern of maternal down-regulation. May be associated . Leucine-rich repeat transmembrane neuronal protein 1. Gene. Lrrtm1. Organism. Mus musculus (Mouse). Status. Reviewed-Annotation score: Annotation.
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Schizophrenia genes, gene expression, and neuropathology: White boxes represent UTRs untranslated regions. ProtoNet; Automatic hierarchical classification of proteins More PhastCons conservation scores derived from multiple alignments of 45 vertebrate genomes to the human genome.
Since LRRTM1 appears to underlie the strongest linkage to schizophrenia in the genome, as identified by a meta-analysis of 20 genomewide linkage scans, 16 it is possible that LRRTM1 dysfunction causes a major, common subtype of schizophrenia. CleanEx database of gene expression profiles More Crow proposed that handedness, brain asymmetry and schizophrenia share an underlying genetic relationship. H-Invitational Database, human transcriptome db More View this region in JBrowse.
Replication validity of genetic association studies. The etiology of schizophrenia and the origin of language: Curr Opin Cell Biol. Expression is upregulated in the mouse brain during embryonic development and early postnatally. MGI cell ggene Source: It is expressed gend the development of specific forebrain structures and shows a variable pattern of maternal downregulation genomic imprinting.
The algorithm is described in the ISO standard. Database for complete collections of gene phylogenies More Humans have the strongest population-level bias in handedness of any primate, 12 and LRRTM1 is a candidate for having had a role in the evolution of this gdne. Similarly, in neuro-2a neuroblastoma cells krrtm1 c is not, but myc-lingo1 is d localized to plasma membrane as detected by live-cell staining. Merlin—rapid analysis of dense genetic maps using sparse gene flow trees.
Number of PDB entities unique chains for this gene: Leucine-rich repeat transmembrane n Eukaryotic Ortholog Groups More UniGene gene-oriented nucleotide sequence clusters More Heritability of lobar brain volumes in twins supports genetic models of cerebral laterality and handedness. LRRTM1 is localized to the cell soma and in the neurites; in neurites it is also localized to lamellipodia of the growth cones arrowheads in h and i. Assessing the frequency of this subtype will require studies in further clinical and epidemiological samples, together with a lrrtm1 definition of the functional genetic and epigenetic variation at the LRRTM1 locus.
Q8K baseline and differential. Database gwne comparative protein structure models More ProteomicsDB bene proteome resource More In northern blot analysis of adult human brain, LRRTM1 also showed predominant expression in forebrain regions including thalamus and cerebral cortex Figure S4.
They mapped the mouse Lrrtm1 gene to chromosome 6C3, which shares homology of synteny with human chromosome 2p However, it is also possible that the failure to replicate the association with handedness was due to low power and a relatively small replication sample in our study.
LRRTM1 leucine rich repeat transmembrane neuronal 1 [ (human)]
Dlx5, the mouse homologue of the human-imprinted DLX5 gene, is biallelically expressed in the mouse brain. The striking signal in caudate and putamen in human Figure 4 was not present in mouse, at least not at E15 and in adult.
Support Center Support Center. A lrgtm1 to all MIMmatch users is the option to sign up for updates on new gene-phenotype relationships. Q86UE6 Secondary accession number s: LRRTM1 aids in the assembly of complex retinogenciulate synapses in mice, which are believed to help process complex visual signals. We also showed that LRRTM1 is expressed during the development of specific forebrain structures, and thus could influence neuronal differentiation and connectivity.
Molecular Function carbohydrate derivative binding cytoskeletal protein binding DNA binding enzyme regulator hydrolase ligase lipid binding oxidoreductase RNA binding signaling receptor activity signaling receptor binding transcription transferase transporter. Significance of linkage is shown on a logarithmic scale.
There is a high level of discordance in imprinting between humans and mice; 32 the gene DLX5 is an example. National Institutes of Health. R-HSA Neurexins and neuroligins. We analyzed methylation within 2 CpG islands that correspond to the predicted promoter and gehe exon of LRRTM1, and a third island roughly 18 kb upstream of LRRTM1, in 17 lymphoblastoid cell lines and 17 human post-mortem brain samples, but we did not find evidence that these CpG islands are differentially methylated regions DMRs data genee shown.
RCSB PDB – Gene View – LRRTM1 – leucine rich repeat transmembrane neuronal 1
OMIM is intended gee use primarily by physicians and other professionals concerned with genetic disorders, by genetics researchers, and by advanced students in science and medicine.
Conflicting reports of imprinting status of human GRB10 in developing brain: Gfne gene is imprinted, being predominantly expressed from the paternal allele and showing a variable pattern of maternal down-regulation. The block in LTP could be rescued by expression of full-length Lrrtm2 or Lrrtm2 lacking its intracellular domain, but not by Lrrtm4 Supplementary Figure S5 jpeg 54K Click here to view.
EMBL nucleotide sequence database More The absence of signal in the subventricular zone argues against a direct involvement in neurogenesis Figure 4. It is useful for tracking sequence updates. Supplementary Figure S2 jpeg 37K Click here to view. Eukaryotic Ortholog Groups More The haplotype varied in frequency between 7.